Analysis of DevR regulated genes in Mycobacterium tuberculosis

摘要

The DevRS two component system of Mycobacterium tuberculosis is responsiblefor its dormancy in host and becomes operative under hypoxic condition. It isexperimentally known that phosphorylated DevR controls the expression ofseveral downstream genes in a complex manner. In the present work we propose atheoretical model to show role of binding sites in DevR mediated geneexpression. Individual and collective role of binding sites in regulating DevRmediated gene expression has been shown via modeling. Objective of the presentwork is two fold. First, to describe qualitatively the temporal dynamics ofwild type genes and their known mutants. Based on these results we propose thatDevR controlled gene expression follows a specific pattern which is efficientin describing other DevR mediated gene expression. Second, to analyze behaviorof the system from information theoretical point of view. Using the tools ofinformation theory we have calculated molecular efficiency of the system andhave shown that it is close to the maximum limit of isothermal efficiency.